An Endeavor in the Reaction-Based Approach to Fluorescent Probes for Biorelevant Analytes: Challenges and Achievements

S Singha, YW Jun, S Sarkar, KH Ahn

Acc. Chem. Res., 2019 Accepted manuscript

DOI: 10.1021/acs.accounts.9b00314

Modified Isoindolediones as Bright Fluorescent Probes for Cell and Tissue Imaging

O Vakuliuk, YW Jun, K Vygranenko, G Clermont, YJ Reo, M Blanchard-Desce, KH Ahn and DT Gryko

Chem. Eur. J. 2019 Accepted manuscript

DOI: org/10.1002/chem.201902534

Far-Red/Near-Infrared Emitting, Two-Photon Absorbing, and Bio-Stable Amino-Si-Pyronin Dyes

KH Kim, S Singha, YW Jun, YJ Reo, HR Kim, HG Ryu, S Bhunia and KH Ahn 

Chem. Sci., 2019, Accepted Manuscript 

DOI: 10.1039/C9SC02287B

A Benzopyronin-Based Two-Photon Fluorescent Probe for Ratiometric Imaging of Lysosomal Bisulfite with Complete Spectral Separation

U Tamima, M Santra, CW Song, YJ Reo & KH Ahn

Anal. Chem. 2019, XXX, XXX−XXX

DOI: 10.1021/acs.analchem.9b02384

A rationally designed polarity–viscosity sensitive probe for imaging lipid droplets

CW Song, U Tamima, YJ Reo, MC Dai, S Sarkar, KH Ahn

Dyes and Pigments, 2019, 171, 107718

DOI: 10.1016/j.dyepig.2019.107718

Molecular Probes for Fluorescent Imaging of ATP in Cell and Tissue

Y. W. Jun,  S. Sarkar,  K. H. Kim,  K. H. Ahn

ChemPhotoChem 2019, 3, 214

DOI: 10.1002/cptc.201900001

Frontiers in Probing Alzheimer’s Disease Biomarkers with Fluorescent Small-Molecules

Y. W. Jun, S. W. Cho, J. Y. Jung, Y. B. Huh, Y. S. Kim, D. K. Kim and K. H. Ahn

ACS Cent. Sci. 2019, 52, 209

DOI: 10.1021/acscentsci.8b00951

Ratiometric fluorescence detection of Cu(II) with a keto-dipicolylamine ligand: A mechanistic implication

S. W. Cho, A. S. Rao, S. Bhunia, Y. J. Reo, S. Singha, K. H. Ahn

Sensors & Actuators: B. Chemical  2019, 279, 204

DOI: 10.1016/j.snb.2018.09.122

A benzocoumarin based two-photon fluorescent probe for ratiometric detection of bisulfite

U. Tamima, S. Singha, H. R. Kim, Y. J. Reo, Y. W. Jun, A. Dasc, K. H. Ahn

Sensors & Actuators: B. Chemical 2018, 277, 576

DOI: 10.1016/j.snb.2018.09.052

Dual probing of redox species, NAD(P)H and HOCl, with a benzo[a]phenoxazine-based far red-emitting dye

M. Santra, S. Sarkar, Y. W. Jun, Y. J. Reo and K. H. Ahn

Tetrahedron Lett., 2018, 59, 3210-3213

DOI: 10.1016/j.tetlet.2018.07.03

Exploration of Molecular Shape-Dependent Luminescence Behavior: Fluorogenic Organic Nanoparticles Based on Bent Shaped Excited-State Intramolecular Proton-Transfer Dyes

M. Santra, Y. W. Jun, Y. J. Reo, S. Sarkar, W. Choi, J. E. Kwon, S. Y. Park and K. H. Ahn

ACS Appl. Bio Mater., 2018, 1, 136-145

DOI: 10.1021/acsabm.8b00040

Two-photon absorbing 8-hydroxy-benzo[g]coumarins with giant Stokes shifts: an environment-insensitive dye platform for probing biomolecules

S. Sarkar, M. Santra, S. Singha, Y. W. Jun, Y. J. Reo, H. R. Kim and K. H. Ahn

J. Mater. Chem. B, 2018, 6, 4446-4452

DOI: 10.1039/C8TB01144C

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production

Longchamp, Mirabella, Arduini, MacArthur, Das, Treviño-Villarreal, Hine, Ben-Sahra, Knudsen, Brace, Reynolds, Mejia, Tao, Sharma, Wang, Corpataux, Haefliger, K. H. Ahn , Lee, Manning, Sinclair, Chen, Ozaki, Mitchell

Cell, 2018, 173, 117–129

DOI: 10.1016/j.cell.2018.03.001

A Ratiometric Two‐Photon Fluorescent Probe for Tracking the Lysosomal ATP Level: Direct in cellulo Observation of Lysosomal Membrane Fusion Processes

Y. W. Jun, T. Wang, S. Hwang, D. Kim, D. Ma, K. H. Kim, S. Kim, J. Jung and K. H. Ahn

Angew. Chem. Int. Ed., 2018, 57, 10142-10147

DOI: 10.1002/anie.201804743

Bidirectional Solvatofluorochromism of a Pyrrolo[3,2-B]pyrrole–diketopyrrolopyrrole Hybrid

H. G. Ryu, M. F. Mayther, J. Tamayo, C. Azarias, E. M. Espinoza, M. Banasiewicz, Ł. G. Łukasiewicz, Y. M. Poronik, A. Jeżewski, J. Clark, J. B. Derr, K. H. Ahn, D. T. Gryko, D. Jacquemin and V. I. Vullev

J. Phys. Chem. C, 2018, 122, 13424-13434

DOI: 10.1021/acs.jpcc.7b11194

Two-photon fluorescent probe for hydrogen sulfide based on a red-emitting benzocoumarin dye

H. G. Ryu, S. Singha, Y. W. Jun, Y. J. Reo and K. H. Ahn

Tetrahedron Lett., 2018, 59, 49.

DOI: 10.1016/j.tetlet.2017.11.050

Addressing the Autofluorescence Issue in Deep Tissue Imaging by Two-Photon Microscopy: Significance of Far-Red Emitting Dyes

Y. W. Jun, H. R. Kim, Y. J. Reo, M. Dai and K. H. Ahn

Chem. Sci., 2017, 8, 7696.

DOI: 10.1039/C7SC03362A

A Two-Photon Fluorescent Probe for Ratiometric Imaging of Endogenous Hypochlorous Acid in Live Cells and Tissues

Y. W. Jun, S. Sarkar, S. Singha, Y. J. Reo, H. R. Kim, J. -J. Kim, Y. -T. Chang and K. H. Ahn

Chem. Commun., 2017, 53, 10800.

DOI: 10.1039/C7CC05834A

Two-Photon In Vivo Imaging with Porous Silicon Nanoparticles

D. Kim, D. J. Kang, T. Wang, H. G. Ryu, J. M. Zuidema, J. Joo, M. Kim, Y. Huh, J. Jung, K. H. Ahn, K. H. Kim and M. J. Sailor

Adv. Mater., 2017, 29, 1703309.

DOI: 10.1002/adma.201703309

Fluorescent Labeling of Protein Using Blue-Emitting 8-Amino-BODIPY Derivatives

D. Kim, D. Ma, M. Kim, Y. Jung, N. H. Kim, C. L, S. W. Cho, S. Park, Y. Huh, J. Jung and K. H. Ahn

J. Fluoresc., 2017, 27, 2231.

DOI: 10.1007/s10895-017-2164-5

Fluorescent Labeling of Lysine Residues in Protein Using 8-thiomethyl-BODIPY

D. Kim, S. W. Cho, Y. W. Jun and K. H. Ahn

Bull. Korean. Chem. Soc., 2017, 38, 995.

DOI: 10.1002/bkcs.11213

Fine-Tuning of CD8+ T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus

D. P. Champagne, K. M. Hatle, K. A. Fortner, A. D. Alessandro, T. M. Thornton, R. Yang, D. Torralba, J. Tomas-Cortazar, Y. W. Jun, K. H. Ahn, K. C. Hansen, L. Haynes, J. Anguita, and M. Rincon

Imnunity., 2016, 44, 1299

DOI: 10.1016/j.immuni.2016.02.018

Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production

C. Hine, H-J. Kim, Y. Zhu, E. Harputlugil, A. Longchamp, M. S. Matos, P. Ramadoss, K. Bauerle, L. Brace, J. M. Asara, C. K. Ozaki, S. Cheng, S. Singha, K. H. Ahn, A. Kimmeleman, F. M. Fisher, P Pissios, D. J. Withers, C. Selman, R. Wang, K. Yen, V. D. Longo, P. Cohen, A. Bartke, J. J. Kopchick, R. Miller, A. N. Hollenberg, J. R. Mitchell

Cell Metab., 2017, 25, 1320

DOI: 10.1016/j.cmet.2017.05.003

A sensitive fluorescent probe for the polar solvation dynamics at protein–surfactant interfaces

P. Singh, S. Choudhury, S. Singha, Y. W. Jun, S. Chakraborty, J. Sengupta, R. Das, K. H. Ahn and S. K. Pal

Phys. Chem. Chem. Phys., 2017, 19, 12237.

DOI: 10.1039/c6cp08804j

Symmetry Breaking in Pyrrolo[3,2-b]pyrroles: Synthesis, Solvatofluorochromism and Two-photon Absorption 

Ł. G. Łukasiewicz, H. G. Ryu, A. Mikhaylov, C. Azarias, M. Banasiewicz, B. Kozankiewicz, K. H. Ahn, D. Jacquemin, A. Rebane and D. T. Gryko

Chem. Asian. J., 2017, 12, 1736.

DOI: 10.1002/asia.201700159

Ratiometric Fluorescence Detection of Anthrax Biomarker with Eu(III)-EDTA Functionalized Mixed Poly(diacetylene) Liposomes

H. Seo, S. Singha and K. H. Ahn

Asian. J. Org. Chem., 2017, 6, 1257.

DOI: 10.1002/ajoc.201700158

Lavender violet, blue and pink: A new type of benzo[a]phenoxazinebased dipolar, red-emitting dyes

M. Santra, Y. W. Jun, Y. J. Reo, S. Sarkar and K. H. Ahn

Dyes Pigm., 2017, 142, 161

DOI: 10.1016/j.dyepig.2017.03.031

Water-Soluble Pyrrolo[3,2-b]pyrroles: Synthesis, Luminescenceand Two-Photon Cellular Imaging Properties

M. Santra, Y. W. Jun, J. Bae, S. Sarkar, W. Choi, D. T. Gryko and K. H. Ahn

Asian J. Org. Chem., 2017, 6, 278

DOI: 10.1002/ajoc.201600613

Ratiometric Imaging of Tissue by Two-Photon Microscopy: Observation of a High Level of Formaldehyde around Mouse Intestinal Crypts

S. Singha, Y. W. Jun, J. Bae and K. H. Ahn

Anal. Chem., 2017, 89, 3724

DOI: 10.1021/acs.analchem.7b00044

Detection of Ciprofloxacin in Urine through Sensitized Lanthanide Luminescence

S. Singha and K. H. Ahn

Sensors, 2016, 16, 2065

DOI: 10.3390/s16122065

Close Correlation of Monoamine Oxidase Activity with Progress of Alzheimer’s Disease in Mice, Observed by in Vivo Two-Photon Imaging

D. Kim, S. H. Baik, S. Kang, S. W. Cho, J. Bae, M. Cha, M. J. Sailor, I. Mook, and K. H. Ahn

ACS Cent. Sci., 2016, 2, 967

DOI: 10.1021/acscentsci.6b00309 

A Fluorescent Probe for Bisulfite Ions: Its Application to Two-Photon Tissue Imaging

H. Agarwalla, S. Pai, A. Paul, Y. W. Jun, J. Bae, and K. H. Ahn, D. N. Srivastava, A. Das

J. Mater. Chem. B, 2016,4, 7888

DOI: 10.1039/C6TB02637K

​

A Dipolar Anthracene Dye: Synthesis, Optical Properties and Two-photon Tissue Imaging

H. Moon, Y. W. Jun, D. Kim, H. G. Ryu, T. Wang, K. H. Kim, Y. Huh, J. Jung and K. H. Ahn

Chem. Asian. J., 2016, 11, 2518

DOI: 10.1002/asia.201600986

Thermally Induced Silane Dehydrocoupling on Silicon Nanostructures

D. Kim, J. Joo, Y. Pan, A. Boarino, Y. W. Jun, K. H. Ahn, B. Arkles, M. J. Sailor

Angew. Chem. Int. Ed., 2016, 55, 6423.

DOI: 10.1002/anie.201601010

Dipolar Dyes with Pyrrolo[2,3-b]quinoxaline Skeleton Containing a Cyano Group and a Bridged Tertiary Amino Group – Synthesis, Solvatofluorochromism and Bioimaging

Ł. G. Łukasiewicz, I. Deperasińska, Y. M. Poronik, Y. W. Jun, M. Banasiewicz, B. Kozankiewicz, K. H. Ahn, D. T. Gryko

Chem. Asian. J., 2016, 11, 1718. 

DOI: 10.1002/asia.201600257

Two-Photon Fluorescent Probe for Lysosomal Zinc Ions

H. Lee, C. Cho, H. Seo, S. Singha, Y. W. Jun, K. Lee, Y. Jung, K. Kim, S. Park, S. C. Bae and K. H. Ahn 

Chem. Commun., 2016, 52, 124

DOI: 10.1039/C5CC06976A

Shape-Selective, Stoichiometric Sensing of Fatty Acids with a Mixed Polydiacetylene Liposome

Y. Cho, D. H. Ma and K. H. Ahn 

J. Mater. Chem. C., 2016, 4, 2871. 

DOI: 10.1039/C5TC02770E

Preparation of luminescent lanthanide polymers by ring-opening metathesis polymerization

M. S. Yoon, M. Santra and K. H. Ahn, 

Tetrahedron Lett. 2015, 56, 5573,

DOI:10.1016/j.tetlet.2015.08.042

A Structural Remedy toward Bright Dipolar Fluorophores in Aqueous Media

S. Singha., D. Kim, B. Roy., S. Sambasivan., H. Moon., A. S. Rao., J. Y. Kim., T. Joo., J. W. Park., Y. M. Rhee., T. Wang., K. H. Kim., Y. H. Shin., J. Jung and K. H. Ahn 

Chem. Sci., 2015, 6, 4335

DOI: 10.1039/C5SC01076D

Two-Photon Absorbing Dyes with Minimal Autofluorescence in Tissue Imaging: Application to in vivo Imaging of Amyloid-ß Plaques with a Negligible Background Signal

D. Kim., H. Moon., S. H. Baik., S. Singha., Y. W. Jun., T. Wang., K. H. Kim., B. S. Park., J. Jung., I. M.-Jung and K. H. Ahn

J. Am. Chem. Soc., 2015, 137, 6781

DOI: 10.1021/jacs.5b03548

Fluorescence sensing systems for gold and silver species

S. Singha, D. Kim, H., Seo S.W., Cho K. H. and Ahn K. H.

Chem. Soc. Rev. 2015, 44, 2643

DOI: 10.1039/C4CS00328D

π-Expanded coumarins: synthesis, optical properties and applications

M. Tasior, D. Kim, S. Singha, M. Krzeszewski, K. H. Ahn and D. T. Gryko

J. Mater. Chem. C, 2015, 3, 1421

DOI: 10.1039/C4TC02665A

Molecular-Shape-Dependent Luminescent Behaviour of Dye Aggregates: Bent versus Linear Benzocumarins

Moon H., Qui P. X., Kim D., Kim Y., Park J. W., Lee C. H., Kim H. J., Ayano K., Park S. Y. and Ahn K. H.

Cryst. Growth Des. 2014, 14, 6613

DOI: 10.1021/cg501567s

Toward a Selective, Sensitive, Fast-Responsive, and Biocompatible Two-Photon Probe for Hydrogen Sulfide in Live Cells

S. Singha, D. Kim, H. Moon, T. Wang, K. H. Kim, Y. H. Shin, J. Jung, E. Seo, S. J. Lee and K. H. Ahn

Anal. Chem. 2015, 87, 1188 

DOI: 10.1021/ac503806v

Ratiometric Fluorescence Detection of Cysteine and Homocysteine with a BODIPY Dye by Mimicking the Native Chemical Ligation

Ma D. H., Kim D., Seo E., Lee S. J. and Ahn K. H.

Analyst. 2015, 140, 422-427

DOI: 10.1039/C4AN01791A

An FITC-BODIPY FRET couple: Application to Selective, Ratiometric Detection and Bioimaging of Cysteine

Ma D. H., Kim D., Takuya A., Lee K. H., Kim K. T. and Ahn K. H.

Chem. Asian. J., 2014, 9, 1

DOI: 10.1002/asia.201403073

Synthesis of Benzocoumarins and Characterization of Their Photophysical Properties

Kim D., Qui P. X., Moon H., Jun Y. W. and Ahn K. H. 

Asian J. Org. Chem., 2014, 3, 1089

DOI: 10.1002/ajoc.201402107

Fluorescent Probes for Analysis and Imaging of Monoamine Oxidase Activity

Kim D., Jun Y. W. and Ahn K. H. 

Bull. Korean Chem. Soc., 2014 , 35 , 1269

ISSN 0253-2964

Recent Development of Two-Photon Fluorescent Probes for Bioimaging 

Kim D., Ryu H. G. and Ahn K. H. 

Org. Biomol. Chem., 2014 , 12, 4550

DOI: 10.1039/C4OB00431K

Ground-State Elevation Approach To Suppress Side Reactions in Gold-Sensing Systems Based on Alkyne Activation

Seo H., Jun M. E., Ranganathan K., Lee K. H., Kim K. T., Lim W., Lee Y. M. and Ahn K. H.

Org. Lett., 2014 , 16, 1374

DOI: 10.1021/ol5001389