Research > 2011-present
Publication (2011-Present)
Recently, we have been developing novel fluorescence probes, focusing on two photon absorbing materials as well as bio- and nano materials. After synthesizing bioconjugated molecules of therapeutic activity and nano biosensors for early diagnosis of disease, we look for application of bio-imaging and disease diagnosis.
Fluorophore Labeling of Proteins: a Versatile Trigger–Release–Conjugation Platform Based on the Quinone Methide Chemistry
Discrimination of Invasive Human Skin Tumor Using an Ultrafast ATP–Proton AND-Gate Probe
Y. W. Jun, K. H. Kim, Y. J. Yang, Y. Jung, K. Kim, H. Kim, B. H. Oh, K. H. Ahn
ACS Sens. 2022, 7, 1068–1074.
Y. J. Yang, M. Dai, Y. J. Reo, C. W. Song, S. Sarkar, and K. H. Ahn
Anal. Chem. 2021, 93, 7523–7531.
![2020(A benzo [b] xanthene-derived fluore](https://static.wixstatic.com/media/b23120_95b8d3c59b1642eaa9b6ad4ab1eb3b76~mv2.png/v1/fill/w_215,h_161,al_c,q_85,usm_0.66_1.00_0.01,enc_auto/2020(A%20benzo%20%5Bb%5D%20xanthene-derived%20fluore.png)
Systematic study on discrepancy of fluorescent properties between in solutions and in cells: Super-bright, environment-insensitive benzocoumarin dyes.
Y. J. Reo, Y. W. Jun, S. W. Cho, J. Jeon, H. Roh, S, Singha, M. Dai, S. Sarkar, H. R. Kim, S. Kim, Y. Jin, Y. L. Jung, Y. J. Yang , C. Ban, J. Joo, K. H. Ahn
Chem. Commun. 2020, 56, 10556-10559.
Bidirectional Solvatofluorochromism of a Pyrrolo[3,2-B]pyrrole–diketopyrrolopyrrole Hybrid
Ryu, H. G.; Mayther, M. F.; Tamayo, J.; Azarias, C.; Espinoza, E. M.; Banasiewicz, M. ; Łukasiewicz, Ł. G.; Poronik, Y. M.; Jeżewski, A.; Clark, J.; Derr, J. B.; Ahn, K. H.; Gryko, D. T.; Jacquemin D.; Vullev, V. I.
J Phys Chem C, 2018, 122, 13424-13434.
Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production
Longchamp, A.; Mirabella, T.; Arduini, A.; MacArthur, M. R.; Das, A. Treviño-Villarreal , J. H.; Hine, C.; Ben-Sahra, I.; Knudsen, N. H.; Brace, L. E.; Reynolds, J.; Mejia, P.; Tao, M.; Sharma, G.; Wang, R.; Corpataux, J. M.; Haefliger, J. A.; Ahn, K. H,; Lee, C.; Manning, B. D.; Sinclair, D. A.; Chen, C. S.; Ozaki, C. K.; Mitchell J. R.
Cell, 2018, 173, 117-129.
Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.
Hine, C.; Kim, H.-J.; Zhu, Y.; Harputlugil, E.; Longchamp, A.; Matos, M. S.; Ramadoss, P.; Bauerle, K.; Brace, L.; Asara, J. M.; Ozaki, C. K.; Cheng, S.; Singha, S.; Ahn, K. H.; Kimmelman, A.; Fisher, F. M.; Pissios, P.; Withers, D. J.; Selman, C.; Wang, R.; Yen, K.; Longo, V. D.; Cohen, P.; Bartke, A.; Kopchick, J. J.; Miller, R.; Hollenberg, A. N.; Mitchell, J. R.
Cell Metab. 2017, 25, 1320-1333.
![2017(Symmetry Breaking in Pyrrolo[3,2-B]](https://static.wixstatic.com/media/b23120_7264b8b348464f96961a31176ba95d92~mv2.png/v1/fill/w_215,h_161,al_c,q_85,usm_0.66_1.00_0.01,enc_auto/2017(Symmetry%20Breaking%20in%20Pyrrolo%5B3%2C2-B%5D.png)
![2017(water-soluble pyrrolo[3,2,-b]pyrrol](https://static.wixstatic.com/media/b23120_aa737fb953b041c2882737a2e86d9975~mv2.jpg/v1/fill/w_215,h_164,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/2017(water-soluble%20pyrrolo%5B3%2C2%2C-b%5Dpyrrol.jpg)
.png)
Fine-Tuning of CD8 + T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus
Champagne, D. P.; Hatle, K. M.; Fortner, K. A.; D’Alessandro, A.; Thornton, T. M.; Yang, R.; Torralba, D.; Tomás-Cortázar, J.; Jun, Y. W.; Ahn, K. H.; Hansen, K. C.; Haynes, L.; Anguita, J.; Rincon, M.
Immunity, 2016, 44, 1299–1311.
.png)
![2016(dipolar dyes with pyrrolo[2,3-b]qui](https://static.wixstatic.com/media/b23120_6b8455e4fe7f433ca8114fa7a1f00618~mv2.png/v1/fill/w_215,h_161,al_c,q_85,usm_0.66_1.00_0.01,enc_auto/2016(dipolar%20dyes%20with%20pyrrolo%5B2%2C3-b%5Dqui.png)
Dipolar Dyes with a Pyrrolo[2,3-b]Quinoxaline Skeleton Containing a Cyano Group and a Bridged Tertiary Amino Group: Synthesis, Solvatofluorochromism, and Bioimaging
Łukasiewicz, Ł. G.; Deperasińska, I.; Poronik, Y. M.; Jun, Y. W.; Banasiewicz, M.; Kozankiewicz, B.; Ahn, K. H.; Gryko, D. T.
Chem. Asian J. 2016, 11, 1718–1724.
Two-Photon Absorbing Dyes with Minimal Autofluorescence in Tissue Imaging: Application to in Vivo Imaging of Amyloid‑β Plaques with a Negligible Background Signal
D. Kim, H. Moon, S. H. Baik, S. Singha, Y. W. Jun, T. Wang, K. H. Kim, B. S. Park, J. Jung, I. Mook-Jung, K. H. Ahn.
J. Am. Chem. Soc. 2015, 137, 6781−6789.
A structural remedy toward bright dipolar fluorophores in aqueous media
Singha, S; Kim, D; Roy, B.; Sambasivan, S; Moon, H.; Rao, A. S.; Kim, J. Y.; Joo, T.*; Park, J. W.; Rhee, Y. M.*; Wang, T.; Kim, K. H.; Shin, Y. H.; Jung, J.*; Ahn, K. H.*
Chem. Sci., 2015, 6, 4335–4342.
Stromal Cell Derived Factor-1 (SDF-1) Targeting Reperfusion Reduces Myocardial Infarction in Isolated Rat Hearts
Jang, Y.-H.; Kim, J.-H.; Ban, C.; Ahn, K. H.; Cheong, J.-H.; Kim, H.-H.; Kim, J.-S.; Park, Y.-H.; Kim, J.; Chun, K.-J.; Lee, G.-H.; Kim, M.; Kim, C.; Xu, Z.
Cardiovascular Therapeutics 2011, 30, 264–272.
%E2%80%90Dipicolylamine%E2%80%90Functional.png)
-%20and%20Cu(II)-comp.png)