Research > 2011-present
Publication (2011-Present)
Recently, we have been developing novel fluorescence probes, focusing on two photon absorbing materials as well as bio- and nano materials. After synthesizing bioconjugated molecules of therapeutic activity and nano biosensors for early diagnosis of disease, we look for application of bio-imaging and disease diagnosis.
Ratiometric Imaging of γ-Glutamyl Transpeptidase Unperturbed by pH, Polarity, and Viscosity Changes: A Benzocoumarin-Based Two-Photon Fluorescent Probe
Y. J. Reo, Y. W. Jun, S. Sarkar, M. Dai, K. H. Ahn
Anal. Chem., 2019, 91, 14101.
An Endeavor in the Reaction-Based Approach to Fluorescent Probes for Biorelevant Analytes: Challenges and Achievements
S. Singha, Y. W. Jun, S. Sarkar, K.H. Ahn
Acc. Chem. Res., 2019, 52, 2571.
Modified Isoindolediones as Bright Fluorescent Probes for Cell and Tissue Imaging
Chem. Eur. J. 2019, 25, 13354.
Far-Red/Near-Infrared Emitting, Two-Photon Absorbing, and Bio-Stable Amino-Si-Pyronin Dyes
K. H. Kim, S. Singha, Y. W. Jun, Y. J. Reo, H. R. Kim, H. G Ryu, S. Bhunia, K. H. Ahn
Chem. Sci., 2019, 10, 9028.
DOI: 10.1039/C9SC02287B
U. Tamima, M. Santra, C. W. Song, Y. J. Reo, K. H. Ahn
Anal. Chem. 2019, 91, 10779.
DOI: 10.1021/acs.analchem.9b02384
A rationally designed polarity–viscosity sensitive probe for imaging lipid droplets
C. W. Song, U. Tamima, Y. J. Reo, M. Dai, S. Sarkar, K. H. Ahn
Dyes and Pigments, 2019, 171, 107718.
Molecular Probes for Fluorescent Imaging of ATP in Cell and Tissue
Y. W. Jun, S. Sarkar, K. H. Kim, K. H. Ahn
Chem. Photo. Chem 2019, 3, 214.
DOI: 10.1002/cptc.201900001
Frontiers in Probing Alzheimer’s Disease Biomarkers with Fluorescent Small-Molecules
Y. W. Jun, S. W. Cho, J. Y. Jung, Y. B. Huh, Y. S. Kim, D. K. Kim, K. H. Ahn
ACS Cent. Sci. 2019, 52, 209.
Ratiometric fluorescence detection of Cu(II) with a keto-dipicolylamine ligand: A mechanistic implication
S. W. Cho, A. S. Rao, S. Bhunia, Y. J. Reo, S. Singha, K. H. Ahn
Sensors & Actuators: B. Chemical 2019, 279, 204.
DOI: 10.1016/j.snb.2018.09.122
A benzocoumarin based two-photon fluorescent probe for ratiometric detection of bisulfite
U. Tamima, S. Singha, H. R. Kim, Y. J. Reo, Y. W. Jun, A. Dasc, K. H. Ahn
Sensors & Actuators: B. Chemical 2018, 277, 576.
DOI: 10.1016/j.snb.2018.09.052
Dual probing of redox species, NAD(P)H and HOCl, with a benzo[a]phenoxazine-based far red-emitting dye
M. Santra, S. Sarkar, Y. W. Jun, Y. J. Reo and K. H. Ahn
Tetrahedron Lett., 2018, 59, 3210.
DOI: 10.1016/j.tetlet.2018.07.03
Exploration of Molecular Shape-Dependent Luminescence Behavior: Fluorogenic Organic Nanoparticles Based on Bent Shaped Excited-State Intramolecular Proton-Transfer Dyes
M. Santra, Y. W. Jun, Y. J. Reo, S. Sarkar, W. Choi, J. E. Kwon, S. Y. Park and K. H. Ahn
ACS Appl. Bio Mater., 2018, 1, 136.
Two-photon absorbing 8-hydroxy-benzo[g]coumarins with giant Stokes shifts: an environment-insensitive dye platform for probing biomolecules
S. Sarkar, M. Santra, S. Singha, Y. W. Jun, Y. J. Reo, H. R. Kim and K. H. Ahn
J. Mater. Chem. B, 2018, 6, 4446.
Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production
Longchamp, Mirabella, Arduini, MacArthur, Das, Treviño-Villarreal, Hine, Ben-Sahra, Knudsen, Brace, Reynolds, Mejia, Tao, Sharma, Wang, Corpataux, Haefliger, K. H. Ahn , Lee, Manning, Sinclair, Chen, Ozaki, Mitchell
Cell, 2018, 173, 117.
DOI: 10.1016/j.cell.2018.03.001
A Ratiometric Two‐Photon Fluorescent Probe for Tracking the Lysosomal ATP Level: Direct in cellulo Observation of Lysosomal Membrane Fusion Processes
Y. W. Jun, T. Wang, S. Hwang, D. Kim, D. Ma, K. H. Kim, S. Kim, J. Jung and K. H. Ahn
Angew. Chem. Int. Ed., 2018, 57, 10142.
Bidirectional Solvatofluorochromism of a Pyrrolo[3,2-B]pyrrole–diketopyrrolopyrrole Hybrid
H. G. Ryu, M. F. Mayther, J. Tamayo, C. Azarias, E. M. Espinoza, M. Banasiewicz, Ł. G. Łukasiewicz, Y. M. Poronik, A. Jeżewski, J. Clark, J. B. Derr, K. H. Ahn, D. T. Gryko, D. Jacquemin and V. I. Vullev
J. Phys. Chem. C, 2018, 122, 13424.
Two-photon fluorescent probe for hydrogen sulfide based on a red-emitting benzocoumarin dye
H. G. Ryu, S. Singha, Y. W. Jun, Y. J. Reo and K. H. Ahn
Tetrahedron Lett., 2018, 59, 49.
Addressing the Autofluorescence Issue in Deep Tissue Imaging by Two-Photon Microscopy: Significance of Far-Red Emitting Dyes
Y. W. Jun, H. R. Kim, Y. J. Reo, M. Dai and K. H. Ahn
Chem. Sci., 2017, 8, 7696.
A Two-Photon Fluorescent Probe for Ratiometric Imaging of Endogenous Hypochlorous Acid in Live Cells and Tissues
Y. W. Jun, S. Sarkar, S. Singha, Y. J. Reo, H. R. Kim, J. -J. Kim, Y. -T. Chang and K. H. Ahn
Chem. Commun., 2017, 53, 10800.
Two-Photon In Vivo Imaging with Porous Silicon Nanoparticles
D. Kim, D. J. Kang, T. Wang, H. G. Ryu, J. M. Zuidema, J. Joo, M. Kim, Y. Huh, J. Jung, K. H. Ahn, K. H. Kim and M. J. Sailor
Adv. Mater., 2017, 29, 1703309.
Fluorescent Labeling of Protein Using Blue-Emitting 8-Amino-BODIPY Derivatives
D. Kim, D. Ma, M. Kim, Y. Jung, N. H. Kim, C. L, S. W. Cho, S. Park, Y. Huh, J. Jung and K. H. Ahn
J. Fluoresc., 2017, 27, 2231.
Fluorescent Labeling of Lysine Residues in Protein Using 8-thiomethyl-BODIPY
D. Kim, S. W. Cho, Y. W. Jun and K. H. Ahn
Bull. Korean. Chem. Soc., 2017, 38, 995.
Fine-Tuning of CD8+ T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus
D. P. Champagne, K. M. Hatle, K. A. Fortner, A. D. Alessandro, T. M. Thornton, R. Yang, D. Torralba, J. Tomas-Cortazar, Y. W. Jun, K. H. Ahn, K. C. Hansen, L. Haynes, J. Anguita, and M. Rincon
Imnunity., 2016, 44, 1299
Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production
C. Hine, H-J. Kim, Y. Zhu, E. Harputlugil, A. Longchamp, M. S. Matos, P. Ramadoss, K. Bauerle, L. Brace, J. M. Asara, C. K. Ozaki, S. Cheng, S. Singha, K. H. Ahn, A. Kimmeleman, F. M. Fisher, P Pissios, D. J. Withers, C. Selman, R. Wang, K. Yen, V. D. Longo, P. Cohen, A. Bartke, J. J. Kopchick, R. Miller, A. N. Hollenberg, J. R. Mitchell
Cell Metab., 2017, 25, 1320
A sensitive fluorescent probe for the polar solvation dynamics at protein–surfactant interfaces
P. Singh, S. Choudhury, S. Singha, Y. W. Jun, S. Chakraborty, J. Sengupta, R. Das, K. H. Ahn and S. K. Pal
Phys. Chem. Chem. Phys., 2017, 19, 12237.
Symmetry Breaking in Pyrrolo[3,2-b]pyrroles: Synthesis, Solvatofluorochromism and Two-photon Absorption
Ł. G. Łukasiewicz, H. G. Ryu, A. Mikhaylov, C. Azarias, M. Banasiewicz, B. Kozankiewicz, K. H. Ahn, D. Jacquemin, A. Rebane and D. T. Gryko
Chem. Asian. J., 2017, 12, 1736.
Ratiometric Fluorescence Detection of Anthrax Biomarker with Eu(III)-EDTA Functionalized Mixed Poly(diacetylene) Liposomes
H. Seo, S. Singha and K. H. Ahn
Asian. J. Org. Chem., 2017, 6, 1257.
Lavender violet, blue and pink: A new type of benzo[a]phenoxazinebased dipolar, red-emitting dyes
M. Santra, Y. W. Jun, Y. J. Reo, S. Sarkar and K. H. Ahn
Dyes Pigm., 2017, 142, 161
Water-Soluble Pyrrolo[3,2-b]pyrroles: Synthesis, Luminescenceand Two-Photon Cellular Imaging Properties
M. Santra, Y. W. Jun, J. Bae, S. Sarkar, W. Choi, D. T. Gryko and K. H. Ahn
Asian J. Org. Chem., 2017, 6, 278
Ratiometric Imaging of Tissue by Two-Photon Microscopy: Observation of a High Level of Formaldehyde around Mouse Intestinal Crypts
S. Singha, Y. W. Jun, J. Bae and K. H. Ahn
Anal. Chem., 2017, 89, 3724
DOI: 10.1021/acs.analchem.7b00044
Detection of Ciprofloxacin in Urine through Sensitized Lanthanide Luminescence
S. Singha and K. H. Ahn
Sensors, 2016, 16, 2065
DOI: 10.3390/s16122065
Close Correlation of Monoamine Oxidase Activity with Progress of Alzheimer’s Disease in Mice, Observed by in Vivo Two-Photon Imaging
D. Kim, S. H. Baik, S. Kang, S. W. Cho, J. Bae, M. Cha, M. J. Sailor, I. Mook, and K. H. Ahn
ACS Cent. Sci., 2016, 2, 967
DOI: 10.1021/acscentsci.6b00309
A Fluorescent Probe for Bisulfite Ions: Its Application to Two-Photon Tissue Imaging
H. Agarwalla, S. Pai, A. Paul, Y. W. Jun, J. Bae, and K. H. Ahn, D. N. Srivastava, A. Das
J. Mater. Chem. B, 2016,4, 7888
DOI: 10.1039/C6TB02637K
A Dipolar Anthracene Dye: Synthesis, Optical Properties and Two-photon Tissue Imaging
H. Moon, Y. W. Jun, D. Kim, H. G. Ryu, T. Wang, K. H. Kim, Y. Huh, J. Jung and K. H. Ahn
Chem. Asian. J., 2016, 11, 2518
DOI: 10.1002/asia.201600986
Thermally Induced Silane Dehydrocoupling on Silicon Nanostructures
D. Kim, J. Joo, Y. Pan, A. Boarino, Y. W. Jun, K. H. Ahn, B. Arkles, M. J. Sailor
Angew. Chem. Int. Ed., 2016, 55, 6423.
DOI: 10.1002/anie.201601010
Dipolar Dyes with Pyrrolo[2,3-b]quinoxaline Skeleton Containing a Cyano Group and a Bridged Tertiary Amino Group Synthesis, Solvatofluorochromism and Bioimaging
Ł. G. Łukasiewicz, I. Deperasińska, Y. M. Poronik, Y. W. Jun, M. Banasiewicz, B. Kozankiewicz, K. H. Ahn, D. T. Gryko
Chem. Asian. J., 2016, 11, 1718.
DOI: 10.1002/asia.201600257
Two-Photon Fluorescent Probe for Lysosomal Zinc Ions
H. Lee, C. Cho, H. Seo, S. Singha, Y. W. Jun, K. Lee, Y. Jung, K. Kim, S. Park, S. C. Bae and K. H. Ahn
Chem. Commun., 2016, 52, 124
DOI: 10.1039/C5CC06976A
Shape-Selective, Stoichiometric Sensing of Fatty Acids with a Mixed Polydiacetylene Liposome
Y. Cho, D. H. Ma and K. H. Ahn
J. Mater. Chem. C., 2016, 4, 2871.
DOI: 10.1039/C5TC02770E
Preparation of luminescent lanthanide polymers by ring-opening metathesis polymerization
M. S. Yoon, M. Santra and K. H. Ahn,
Tetrahedron Lett. 2015, 56, 5573,
DOI:10.1016/j.tetlet.2015.08.042
A Structural Remedy toward Bright Dipolar Fluorophores in Aqueous Media
S. Singha., D. Kim, B. Roy., S. Sambasivan., H. Moon., A. S. Rao., J. Y. Kim., T. Joo., J. W. Park., Y. M. Rhee., T. Wang., K. H. Kim., Y. H. Shin., J. Jung and K. H. Ahn
Chem. Sci., 2015, 6, 4335
DOI: 10.1039/C5SC01076D
Two-Photon Absorbing Dyes with Minimal Autofluorescence in Tissue Imaging: Application to in vivo Imaging of Amyloid-ß Plaques with a Negligible Background Signal
D. Kim., H. Moon., S. H. Baik., S. Singha., Y. W. Jun., T. Wang., K. H. Kim., B. S. Park., J. Jung., I. M.-Jung and K. H. Ahn
J. Am. Chem. Soc., 2015, 137, 6781
DOI: 10.1021/jacs.5b03548
Fluorescence sensing systems for gold and silver species
S. Singha, D. Kim, H., Seo S.W., Cho K. H. and Ahn K. H.
Chem. Soc. Rev. 2015, 44, 2643
DOI: 10.1039/C4CS00328D
π-Expanded coumarins: synthesis, optical properties and applications
M. Tasior, D. Kim, S. Singha, M. Krzeszewski, K. H. Ahn and D. T. Gryko
J. Mater. Chem. C, 2015, 3, 1421
DOI: 10.1039/C4TC02665A
Molecular-Shape-Dependent Luminescent Behaviour of Dye Aggregates: Bent versus Linear Benzocumarins
Moon H., Qui P. X., Kim D., Kim Y., Park J. W., Lee C. H., Kim H. J., Ayano K., Park S. Y. and Ahn K. H.
Cryst. Growth Des. 2014, 14, 6613
DOI: 10.1021/cg501567s
Toward a Selective, Sensitive, Fast-Responsive, and Biocompatible Two-Photon Probe for Hydrogen Sulfide in Live Cells
S. Singha, D. Kim, H. Moon, T. Wang, K. H. Kim, Y. H. Shin, J. Jung, E. Seo, S. J. Lee and K. H. Ahn
Anal. Chem. 2015, 87, 1188
DOI: 10.1021/ac503806v
Ratiometric Fluorescence Detection of Cysteine and Homocysteine with a BODIPY Dye by Mimicking the Native Chemical Ligation
Ma D. H., Kim D., Seo E., Lee S. J. and Ahn K. H.
Analyst. 2015, 140, 422-427
DOI: 10.1039/C4AN01791A
An FITC-BODIPY FRET couple: Application to Selective, Ratiometric Detection and Bioimaging of Cysteine
Ma D. H., Kim D., Takuya A., Lee K. H., Kim K. T. and Ahn K. H.
Chem. Asian. J., 2014, 9, 1
DOI: 10.1002/asia.201403073
Synthesis of Benzocoumarins and Characterization of Their Photophysical Properties
Kim D., Qui P. X., Moon H., Jun Y. W. and Ahn K. H.
Asian J. Org. Chem., 2014, 3, 1089
DOI: 10.1002/ajoc.201402107
Fluorescent Probes for Analysis and Imaging of Monoamine Oxidase Activity
Kim D., Jun Y. W. and Ahn K. H.
Bull. Korean Chem. Soc., 2014 , 35 , 1269
ISSN 0253-2964
Recent Development of Two-Photon Fluorescent Probes for Bioimaging
Kim D., Ryu H. G. and Ahn K. H.
Org. Biomol. Chem., 2014 , 12, 4550
DOI: 10.1039/C4OB00431K
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