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'BRIC-한빛사(한국을 빛내는 사람들)논문 (High Impact Journal Paper) 선정'

한국을 빛낸 사람들 (이하 한빛사)에서 선정한 high impact jouranl paper에 안교한 교수님 연구실에서 보고한 JACS논문이 선정되었다. 생물학연구정보센터(Biological Research Information Center, BRIC)은 생물학 분야에서의 국가 경쟁력 확보에 있어서 정보 및 정보 분석도구의 중요성에 대한 인식을 바탕으로 한국과학재단과 포항공과대학교의 지원으로 1996년 1월에 설립되었고 같은 해 5월 인터넷을 통한 정보 서비스를 시작하였다. 현재의 센터는 국내 생물학 연구자들의 정보 수집의 장 뿐만 아니라 서로간의 의견교환이 가능한 interactive discussion forum의 역할을 하고있으며 생물학 연구정보의 교류활성화와 더 나은 연구 환경을 만들기 위한 주체의 역할을 하고있다.


J. Am. Chem. Soc., May 7, 2015 | DOI: 10.1021/jacs.5b03548

Two-Photon Absorbing Dyes with Minimal Autofluorescence in Tissue Imaging: Application to in Vivo Imaging of Amyloid-β Plaques with a Negligible Background Signal

Dokyoung Kim †∥, Hyunsoo Moon †∥, Sung Hoon Baik ‡∥, Subhankar Singha †∥, Yong Woong Jun†, Taejun Wang §, Ki Hean Kim *§, Byung Sun Park ⊥, Junyang Jung ⊥, Inhee Mook-Jung *‡, and Kyo Han Ahn *†

† Department of Chemistry, Center for Electro-Photo Behaviors in Advanced Molecular Systems, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, Gyungbuk 790-784, Republic of Korea

‡ Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehak-Ro, Jongro-Gu, Seoul 110-799, Republic of Korea

§ Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, Gyungbuk 790-784, Republic of Korea

⊥ Department of Anatomy and Neurobiology, School of Medicine, Biomedical Science Institute, Kyung Hee University, 26 Kyungheedae-Ro, Dongdaemun-Gu, Seoul 130-701, Republic of Korea

*Corresponding authors

∥These authors contributed equally.


Fluorescence imaging of tissues offer an essential means for studying biological systems. Autofluorescence becomes a serious issue in tissue imaging under excitation at UV-vis wavelengths where biological molecules compete with the fluorophore. To address this critical issue, a novel class of fluorophores that can be excited at ∼900 nm under two-photon excitation conditions and emits in the red wavelength region (≥600 nm) has been disclosed. The new π-extended dipolar dye system shows several advantageous features including minimal autofluorescence in tissue imaging and pronounced solvent-sensitive emission behavior, compared with a widely used two-photon absorbing dye, acedan. As an important application of the new dye system, one of the dyes was developed into a fluorescent probe for amyloid-β plaques, a key biomarker of Alzheimer’s disease. The probe enabled in vivo imaging of amyloid-β plaques in a disease-model mouse, with negligible background signal. The new dye system has great potential for the development of other types of two-photon fluorescent probes and tags for imaging of tissues with minimal autofluorescence.

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